Women 30 to 65 should be screened every three years if the Pap test is used alone and every five years if the HPV test is used in combination with the Pap test. Women over 65 do not need to be screened if they have been screened according to the guidelines before they reached 65 and are otherwise not at a high risk for cervical cancer. There are 12 high-risk HPV types: HPV 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, and 59. Two of these, HPV 16 and HPV 18, are responsible for most HPV-related cancers. Low-risk HPV t ypes rarely cause cancer, although a few low-risk HPV types can cause warts on or around the genitals, anus, mouth, or throat. The L1 HPV test was still negative and the E6/E7 HPV test was still positive. Despite several multiple treatment modalities she succumbed of her disease two years later leaving behind a young family. Conclusion: HPV test looking only at L1 can give false negative results if the virus is integrated in the human genome. By “false positive” screening tests, we do not mean that HPV is not present, which has not been reported to be a problem for HPV nucleic acid detection methods. Rather, we are referring to the detection of HPV infections that are not destined to cause cervical cancer. How abnormalities can be missed. We will check your screening sample for HPV first. If we do not find HPV, we do not need to check for abnormal (pre-cancerous) cells. This is because your risk of developing cervical cancer is very low if you do not have HPV. But in some cases people who have a negative HPV test result go on to develop cancer. HPV infection can increase a man's risk of getting genital cancers, although these cancers are not common. HPV can also cause genital warts in men, just as in women. More than half of men who are HPV tests can find any of the high-risk types of HPV that are commonly found in cervical cancer. Current guidelines for cervical cancer screening are: Women should start screening with the Pap test at age 21. (Screening is not recommended for women under age 21.) Starting at age 30, women have three options available for screening: An at-home HPV testing kit can provide a more discreet way for someone to test for HPV in their own privacy. They can be purchased online starting at $90. The type of HPV – types 16 and 18 cause 70% of cervical cancers and precancerous lesions. Status of immune system – those with compromised immune systems are more likely to have persistent HPV, and progression to precancer and cancer. The presence of other STDs such as herpes, chlamydia and gonorrhea. Being young with a first birth. Furthermore, they mentioned that increased numbers of a false negative HPV test results might occur like in our study . The false negative rate of the HPV test in ASCUS/LSIL has been reported as 3.7% to 18.2% [14, 15, 16]. Jastania et al . reported the characteristics of false negative HC II testing. They stated that HPV DNA was present in the ihvLrX.